Serzone for Depression.
The following information is intended to supplement, not
substitute, the expertise and judgment of your physician,
pharmacist or other healthcare professional. It should not be
construed to indicate that using Celexa is safe or appropriate for
you.
People seeking depression relief should
carefully evaluate Serzone information and
side effects before
deciding to take Serzone. Consult your healthcare professional
before using nefazodone.
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to elevate mood without the potentially harmful side effects
commonly associated with Serzone. Self-help techniques,
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What is Serzone used for? Serzone is in a class of
antidepressant drugs used to relieve symptoms of depression.
Drug Interaction Warnings for Serzone:
The following drugs can have very serious interactions that could
lead to seizures, heart damage, and even death when taken with
Serzone;
_ Astemizole (Hismanal).
_ Cisapride (Propulsid).
_ Pimozide (Orap).
_ Terfenadine (Seldane, Seldane-D).
_ Carbamazepine (Tegretol, Tegretol XR, Epitol, Carbatrol).
_ Monoamine oxidase (MAO) inhibitors.
_ Triazolam (Halcion).
FDA Warnings for Serzone: The FDA issued a public health
alert for Serzone in March 2004 warning that this antidepressant
can lead to deeper depression and suicide. The FDA recommends that
health care providers warn patients, their families and their
caregivers to be alert for agitation, irritability, suicide and
worsening depression while using Serzone. The FDA also recommends
that health care providers closely monitor adult and children
treated with nefazodone for worsening of depression or suicidal
tendencies, especially at the beginning of therapy or when the
dose either increases or decreases.
The FDA issued a Public Health Advisory in October 2003 about
increased reports of suicidal thinking, suicide attempts,
hostility and self-harm in children using Serzone. The FDA urges
that Serzone be used with caution in children. Parents of children
using Serzone should consult the prescribing physician immediately
to discuss the suicide risks involved in taking Serzone.
It should be noted that the safety and effectiveness of Serzone in
pediatric patients has not been established. In clinical trials,
only Prozac (fluoxetine) has been found effective for children.
General Serzone Precautions:
_ Serzone has been associated with serious liver problems,
sometimes resulting in liver transplant or death. Contact your
doctor immediately if you experience early signs of liver problems
including; yellowing of the skin or eyes; unusually dark urine;
loss of appetite that lasts several days or longer; severe nausea;
or stomach pain.
_ Do not take Serzone if you have taken a monoamine oxidase
inhibitor (MAOI) within the last 14 days. A dangerous drug
interaction can occur if combined with MAO inhibitors.
_ If you skip the missed dose and take only the next one as
directed. Do not take a double dose of nefazodone. Overdose is
possible.
_ Serzone may cause dizziness. If you experience dizziness, avoid
driving, operating machinery, or performing other hazardous
activities.
_ You are more likely to experience side effects from Serzone if
you are over the age of 60.
_ Rise slowly when rising from a sitting or lying position to
prevent dizziness or possible falls.
_ It is not known whether Serzone will harm an unborn baby or a
nursing baby.
_ Nefazodone may impair judgment, thinking, or motor skills.
Patients using Serzone should exercise caution until they have
adapted to therapy.
Serzone can cause serious side effects. Only you can decide if
Serzone is the best means of treating depression symptoms. It is
important for people currently taking Serzone to discuss side
effect concerns with their physician.
Serzone Side Effects:
_ Agitation.
_ Irritability.
_ Deepened depression.
_ Increased risk of suicide.
_ High blood pressure.
_ Low blood pressure.
_ Dizziness.
_ Fainting.
_ Serious liver problems resulting in liver transplant or death.
_ Prolonged, painful, or inappropriate erections.
_ Fast or irregular heartbeat or pulse.
_ Drowsiness.
_ Insomnia.
_ Nausea.
_ Weakness.
_ Blurred or abnormal vision.
_Constipation.
_ Dry mouth.
Contact your doctor immediately if you experience: An
allergic reaction (difficulty breathing; closing of the throat;
swelling of the lips, face, or tongue; or hives). Stop taking
Serzone and contact your doctor immediately if you experience
early signs of liver problems including; yellowing of the skin or
eyes; unusually dark urine; loss of appetite that lasts several
days or longer; severe nausea; or stomach pain. Contact your
doctor immediately or seek emergency medical treatment if you also
experience prolonged, painful, or inappropriate erections. This
could lead to a serious condition requiring surgery.
Before taking Serzone, tell your doctor if you have:
_ Seizures.
_ Liver disease.
_ Kidney disease.
_ Heart disease.
_ High or low blood pressure.
_ Irregular heartbeats.
_ A history of manic episodes.
_ Suicidal thoughts.
What should I avoid while taking Serzone?
_ Use alcohol cautiously while taking Serzone. Alcohol may
increase drowsiness and dizziness.
Symptoms of overdose may include: Symptoms of a Serzone
overdose include drowsiness, nausea, vomiting, and seizures.
What other drugs will affect Serzone? The following drugs
can have very serious interactions that could lead to seizures,
heart damage, and even death when taken with Serzone;
_ Astemizole (Hismanal).
_ Cisapride (Propulsid).
_ Carbamazepine (Tegretol, Tegretol XR, Epitol, Carbatrol).
_ Monoamine oxidase (MAO) inhibitors.
_ Pimozide (Orap).
_ Terfenadine (Seldane, Seldane-D).
_ Triazolam (Halcion).
Serzone can increase the effects of many other drugs, leading to
serious side effects. If taking Serzone, talk to your doctor and
pharmacist before taking any prescription or over-the-counter
medicines. Do not take nefazodone with the following medicines
without your doctor’s approval:
_ Alprazolam.
_ Atorvastatin , lovastatin or simvastatin.
_ Cyclosporine.
_ Digoxin.
_ Haloperidol.
_ Lorazepam.
_ Phenytoin.
_ Tacrolimus.
_ Warfarin.
_ Drugs other than the above listed may also interact with Serzone.
Talk to your doctor and pharmacist before taking any prescription,
over-the-counter medicines or natural supplements.
*This antidepressant drug
information does not endorse Serzone, diagnose patients or
recommend therapy. The information contained herein is not
intended to cover all possible warnings, uses, precautions, drug
interactions, allergic reactions, or adverse side effects of
Serzone. If you have questions about the drugs you are taking,
check with your health care provider or pharmacist. The
information provided should not be construed to indicate that
Serzone is safe, effective or appropriate.
Do not stop taking Serzone without first talking to your doctor.
Your doctor may need to gradually reduce the dose before stopping
Serzone completely. Suddenly stopping nefazodone may cause
unpleasant and potentially serious side effects.
